Mycobacterium leprae produces extracellular homologs of the antigen 85 complex

Nucleotide sequence of the gene coding for the 85-B antigen of Mycobacterium leprae.

Leila de Mendonga Lima, Jean Content, Hugo van Heuverswyn and Wim Degrave* Department of Biochemistry and Molecular Biology and Laboratory of Hanseniasis, Department of Tropical Medicine, Oswaldo Cruz Institute, FIOCRUZ, Av. Brasil 4365, Rio de Janeiro, RJ, CEP 21045, Brasil, lnstitut Pasteur du Brabant, Department of Virology, B-1180 Brussels and lnnogenetics, Industriepark Zwijnaarde 7, box 4...

Analysis of the genes encoding the antigen 85 complex and MPT51 from Mycobacterium avium.

The components of the fibronectin-binding antigen 85 complex (85A, 85B, and 85C) and the related protein MPB/MPT51 are major secreted proteins in Mycobacterium tuberculosis and Mycobacterium bovis BCG. The fbpA, fbpC, and mpt51 genes encoding 85A, 85C, and MPT51, respectively, were isolated from Mycobacterium avium and sequenced in this study. The structures of these genes, and that of the fbpB...

Inactivation of the Mycobacterium tuberculosis antigen 85 complex by covalent, allosteric inhibitors.

The rise of multidrug-resistant and totally drug-resistant tuberculosis and the association with an increasing number of HIV-positive patients developing tuberculosis emphasize the necessity to find new antitubercular targets and drugs. The antigen 85 (Ag85) complex from Mycobacterium tuberculosis plays important roles in the biosynthesis of major components of the mycobacterial cell envelope. ...

Genetic control of delayed type hypersensitivity to Mycobacterium leprae antigen.

The mechanism of genetic control of Mycobacterium leprae-specific delayed type hypersensitivity (DTH) in mice was investigated in terms of footpad swelling response. Studies with various congenic and recombinant inbred strains of mouse revealed that M. leprae-specific DTH was controlled by genes within the I-A subregion. The footpad swelling response showed an antigen-specific pattern, revealin...

leprae antigen T 5 . T - cell - stimulatory capacity of Mycobacterium